General
Preferred name
Tenovin-6
Synonyms
Tenovin 6 ()
Tenovin 6 (Hydrochloride) ()
Tenovin 2 ()
Tenovin-6 (Hydrochloride) ()
Tenovin 6 Hydrochloride ()
Tenovin-6 Hydrochloride ()
P&D ID
PD010667
CAS
1011557-82-6
1011301-29-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 ¦ÌM, 10 ¦ÌM, and 67 ¦ÌM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)[1][2].
PRICE 85
DESCRIPTION Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 ¦ÌM, 10 ¦ÌM, and 67 ¦ÌM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH)[1][2].
PRICE 79
DESCRIPTION Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 ??M, 10 ??M, and 67 ??M for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
DESCRIPTION Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. (BOC Sciences Bioactive Compounds)
DESCRIPTION Tenovin-6 is a p53 transcriptional activity agonist. (TargetMol Bioactive Compound Library)
DESCRIPTION Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50=10 μM) inhibitor as well as p53 activator. (BOC Sciences Bioactive Compounds)
DESCRIPTION Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
AdooQ Bioactive Compound Library
A12305
Axon Medchem Screening Library
2249
BOC Sciences Bioactive Compounds
tenovin-6-cas-1011557-82-6-item-84-310561
tenovin-6-hydrochloride-cas-1011301-29-3-item-84-463491
Cayman Chemical Bioactives
13086
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
HY-15510
HY-15510B
Selleckchem Bioactive Compound Library
tenovin-6
TargetMol Bioactive Compound Library
T1818
T8480
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
454.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
4.78
TPSA
73.47
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HDAC
SIRT1, SIRT2, SIRT3
Dihydroorotate Dehydrogenase
MDM-2/p53
Sirtuin
Dehydrogenase,p53,Sirtuin
SIRT1
SIRT2
SIRT3
HDAC8
p53
MOA
SIRT inhibitor
Pathway
Autophagy
Chromatin/Epigenetic
DNA Damage/DNA Repair
Metabolism
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
Metabolic Enzyme/Protease
Source data