General
Preferred name
QNZ
Synonyms
EVP4593 ()
CAY10470 ()
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline ()
AG-F-89549 ()
EVP 4593 ()
QNZ (EVP4593) ()
NF-kB activation inhibitor ()
P&D ID
PD010665
CAS
545380-34-5
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This compound potently inhibits nuclear factor-κB (NFκB) activation and LPS-induced TNFα production . Its discovery is reported in where it is compound 11q.
(GtoPdb)
DESCRIPTION
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
11
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
356.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
4.66
TPSA
73.06
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Apoptosis
NF-??b
NF-??
NF-κB
Target
NF-??B
TNF-??
NF-?B inhibitor
TNF Receptor
NF-¦ÊB,TNF-alpha
MOA
NFkB pathway inhibitor
Source data
