General
Preferred name
PP2
Synonyms
PP 2 ()
AG 1879 ()
AGL 1879 ()
PP-2 ()
AG 1879,AGL 1879 ()
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine ()
P&D ID
PD010654
CAS
172889-27-9
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PP2 is a non-selective (pan) inhibitor of Src family tyrosine kinases, used widely to study the biological roles of Src kinases .
(GtoPdb)
DESCRIPTION
PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively.
PRICE
74
DESCRIPTION
Potent, highly selective iNOS inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective Src inhibitor
(Tocriscreen Total)
DESCRIPTION
Potent, selective Src family kinase inhibitor
(Tocriscreen Plus)
DESCRIPTION
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
0
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
301.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.48
TPSA
69.62
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
EGFR
Fyn
JAK2
LCK
SRC
ZAP70
ABL1, LCK, RIPK2, SRC
Lyn
Primary Target
Src Kinases
MOA
Inhibitor
Src Kinase Inhibitors
Src inhibitor
Member status
member
Pathway
Angiogenesis
Chromatin/Epigenetic
JAK/STAT Signaling
Stem Cells
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data
