General
Preferred name
GDC-0152
Synonyms
GDC0152 ()
P&D ID
PD010653
CAS
873652-48-3
Tags
available
drug candidate
Drug indication
Obesity
Cancer
Solid tumour/cancer
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GDC-0152 is reported to be a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins . The compound is a Smac mimetic, and antagonises binding of caspases to BIR domains of IAP proteins. This action restores apoptosis. (GtoPdb)
DESCRIPTION GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.
PRICE 125
DESCRIPTION GDC-0152 is a potent inhibitor of IAPs. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
17810
ChEMBL Drugs
CHEMBL2063869
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12380
DrugMAP
DM1B3UM
EU-OPENSCREEN Bioactive Compound Library
EOS101342
Guide to Pharmacology
7733
MedChem Express Bioactive Compound Library
HY-13638
ReFrame library
Selleckchem Bioactive Compound Library
gdc-0152
TargetMol Bioactive Compound Library
T6299
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
498.24
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
2.81
TPSA
116.32
Fraction CSP3
0.56
Chiral centers
3.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
cIAP1-BIR3
cIAP2-BIR3
IAP
MLXBIR3SG
XIAP-BIR2
XIAP-BIR3
BIRC2, BIRC3, BIRC7, XIAP
MOA
XIAP inhibitor
Pathway
Apoptosis
Source data