General
Preferred name
Stattic
Synonyms
STAT3 Inhibitor V ()
P&D ID
PD010649
CAS
19983-44-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].
PRICE 29
DESCRIPTION Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 ??M) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.
DESCRIPTION Stattic is a potent signal transducer and activator of transcription 3 (STAT3) inhibitor. (Enamine Bioactive Compounds)
DESCRIPTION Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. (BOC Sciences Bioactive Compounds)
DESCRIPTION Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis. (TargetMol Bioactive Compound Library)
DESCRIPTION Antiepileptic; binds SV2A (Tocris Bioactive Compound Library)
Cell lines
14
Organisms
0
Compound Sets
12
AdooQ Bioactive Compound Library
A12733
Axon Medchem Screening Library
2314
BOC Sciences Bioactive Compounds
stattic-cas-19983-44-9-item-173252
Cayman Chemical Bioactives
14590
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Enamine Bioactive Compounds
EBC-12203
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-13818
Selleckchem Bioactive Compound Library
stattic
TargetMol Bioactive Compound Library
T6308
Tocris Bioactive Compound Library
2798
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
210.99
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.35
TPSA
77.28
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
STAT
STAT3
STAT3 inhibitor
Apoptosis related,STAT
Primary Target
STATs
MOA
Inhibitor
Pathway
JAK/STAT Signaling
Stem Cells
Stem Cell/Wnt
Source data