General
Preferred name
pinometostat
Synonyms
EPZ-5676 ()
Pinometostat anhydrous ()
EPZ-005676 ()
EPZ5676 ()
P&D ID
PD010637
CAS
1380288-87-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 1
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pinometostat acts as a DOT1-like histone H3K79 methyltransferase (DOT1L) inhibitor that is being progressed through clinical evaluation in a collaboration between Cellgene and Epizyme, to evaluate its antileukemic efficacy in mixed-lineage leukemia (MLL)-rearranged leukemias. Link to Epizyme's pinometostat webpage here. (GtoPdb)
Cell lines
5
Organisms
0
Compound Sets
9
Cayman Chemical Bioactives
16175
ChEMBL Drugs
CHEMBL3414626
Drug Repurposing Hub
DrugBank
DB12920
EU-OPENSCREEN Bioactive Compound Library
EOS100730
Guide to Pharmacology
7019
MedChem Express Bioactive Compound Library
HY-15593
ReFrame library
TargetMol Bioactive Compound Library
T3099
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
562.34
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
6
Aromatic Ring Count
4
cLogP
3.32
TPSA
151.23
Fraction CSP3
0.6
Chiral centers
4.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
Epigenetics
Target
DOT1L
Histone methyltransferase
MOA
Histone Methyltransferase inhibitor
histone lysine methyltransferase inhibitor
Source data