General
Preferred name
AZD3463
Synonyms
ALK/IGF1R inhibitor ()
AZD 3463 ()
AZD-3463 ()
P&D ID
PD010620
CAS
1356962-20-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD3463 was investigated as a treatement for non-small cell lung cancer (NSCLC) patients who have developed resistance to . AZD3463 inhibits the tyrosine kinases ALK and IGF1R. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox. (GtoPdb)
DESCRIPTION AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells[1][2][3].
PRICE 67
DESCRIPTION AZD-3463 is a potent ALK/IGF1R inhibitor with potential anticancer activity. (BOC Sciences Bioactive Compounds)
DESCRIPTION AZD-3463 (ALK/IGF1R inhibitor), an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
9
Axon Medchem Screening Library
2153
BOC Sciences Bioactive Compounds
azd-3463-cas-1356962-20-3-item-84-462676
Drug Repurposing Hub
DrugMAP
DMAX9C3
EU-OPENSCREEN Bioactive Compound Library
EOS101166
Guide to Pharmacology
7706
MedChem Express Bioactive Compound Library
HY-15609
Selleckchem Bioactive Compound Library
azd3463
TargetMol Bioactive Compound Library
T1967
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
448.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
4.96
TPSA
92.09
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ALK, IGF1R
ALK inhibitor
Anaplastic lymphoma kinase (ALK)
IGF-1R
ALK,Apoptosis related,Autophagy,IGF-1R
ALK
MOA
ALK tyrosine kinase receptor inhibitor, insulin growth factor receptor inhibitor
Pathway
Angiogenesis
Apoptosis
Autophagy
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data