General
Preferred name
P005091
Synonyms
P5091 ()
P 005091 ()
P5091 (P005091) ()
P&D ID
PD010607
CAS
882257-11-6
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 ¦ÌM.
PRICE 70
DESCRIPTION P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 ??M.
DESCRIPTION ALDH1A2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo. The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. (BOC Sciences Bioactive Compounds)
DESCRIPTION P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A13277
Axon Medchem Screening Library
2011
BOC Sciences Bioactive Compounds
p005091-cas-882257-11-6-item-84-462440
Cayman Chemical Bioactives
15224
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMGIR3F
JUMP-MOA Compound Set
2819993
Mcule NIBR MoA Box Subset
MCULE-6661883192
MedChem Express Bioactive Compound Library
HY-15667
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
p5091-p005091
TargetMol Bioactive Compound Library
T6925
Tocris Bioactive Compound Library
4733
ZINC Tool Compounds
ZINC000000125366
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
346.92
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
5.32
TPSA
60.21
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Deubiquitinating Enzymes
MOA
Inhibitor
Ubiquitin C-terminal Hydrolase Inhibitors 7 (USP7| HAUSP) Inhibitors
ubiquitin specific protease inhibitor
Ubiquitin C-terminal Hydrolase Inhibitors 7 (USP7
HAUSP) Inhibitors
Member status
member
Target
USP7
USP7 inhibitor
Deubiquitinase
DUB
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Ubiquitination
Cell Cycle/DNA Damage
Source data