General
Preferred name
TCID
Synonyms
UCH-L3 Inhibitor ()
4,5,6,7-Tetrachloroindan-1,3-dione ()
compound 6 [PMID: 17948018] ()
P&D ID
PD010601
CAS
30675-13-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Compound 6 is reported to inhibit ubiquitin carboxyl-terminal esterase L3 (UCHL3) with >100-fold selectivity over the L2 isozyme (UCHL2) .
(GtoPdb)
DESCRIPTION
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 ¦ÌM[1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons[2].
PRICE
55
DESCRIPTION
TCID (UCH-L3 Inhibitor)(IC50=0.6 ??M) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
DESCRIPTION
Potent ROCK inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
Axon Medchem Screening Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
281.88
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
4.07
TPSA
34.14
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
1
keto_keto_beta_A(68)
c:1-2:c(:c:c:c:c:1)-[#6](=[#8])-[#6;X4]-[#6]-2=[#8]
PAINS Family B
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Deubiquitinating Enzymes
MOA
Inhibitor
Member status
virtual
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Ubiquitination
Cell Cycle/DNA Damage
Target
UCHL3 inhibitor
Deubiquitinase
DUB
UCH-L1
UCH-L3
Source data
