General
Preferred name
AZD-1080
Synonyms
AZD 1080 ()
AZD1080 ()
AZ-11548415 ()
P&D ID
PD010598
CAS
612487-72-6
Tags
available
drug candidate
Drug indication
Alzheimer disease
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD1080 is a potent and selective GSK3 inhibitor. AZD1080 inhibits recombinant human GSK3¦Á and GSK3¦Â with pKi (IC50) of 8.2 (6.9 nM) and 7.5 (31 nM), respectively.
PRICE 93
DESCRIPTION AZD1080 is a brain-permeable GSK3 inhibitor with Ki values of 6.9 nM and 31 nM for GSK3α and GSK3β, respectively. Study showed that AZD1080 inhibited tau phosphorylation in cells. It also suppresses ovarian cancer cell proliferation, invasion, migration, and lamellipodia formation, and induces G1 arrest. (BOC Sciences Bioactive Compounds)
DESCRIPTION AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
12
Axon Medchem Screening Library
2171
BOC Sciences Bioactive Compounds
azd1080-cas-612487-72-6-item-286285
Cayman Chemical Bioactives
16676
ChEMBL Drugs
CHEMBL1969664
DrugMAP
DMIM9N1
EU-OPENSCREEN Bioactive Compound Library
EOS101385
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1969664
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL1969664
MedChem Express Bioactive Compound Library
HY-13862
ReFrame library
Selleckchem Bioactive Compound Library
azd1080
TargetMol Bioactive Compound Library
T1741
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
334.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
2.64
TPSA
85.17
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GSK-3
GSK-3α
GSK-3β
GSK-3¦Á
GSK-3¦Â
MOA
GSK-3 inhibitor
Pathway
PI3K/Akt/mTOR
Stem Cell/Wnt
PI3K/Akt/mTOR signaling
Stem Cells
Source data