General
Preferred name
ML347
Synonyms
ML 347 ()
LDN 193719 ()
LDN-193719 ()
ML-347 ()
P&D ID
PD010595
CAS
1062368-49-3
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ML347 is a selective inhibitor of ALK2 (activin A receptor, type I, ACVR1) compared to ALK3 (bone morphogenetic protein receptor, type IA , BMPR1A) .
(GtoPdb)
DESCRIPTION
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-¦Â1[1][2].
PRICE
62
DESCRIPTION
Potent and selective Ack1 (TNK2) inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective ALK1 and ALK2 inhibitor
(Tocriscreen Plus)
DESCRIPTION
ML347 is a selective BMP receptor inhibitor with IC50 value of 32 nM for ALK2, >300-fold selectivity over ALK3. It also inhibits ALK1 activity with IC50 value of 46 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
MLP Probes
MLSMR Probes +
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
352.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
5
cLogP
4.62
TPSA
52.31
Fraction CSP3
0.05
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
Probe
Target
TGF-β Receptor
BMP4, ALK2 (ACVR1)
TGF-¦Â Receptor
TGF-??Receptor
ACVR1, ACVRL1, BMPR1A
ALK1
ALK2
ALK3
ALK6
Target Type
Enzyme-Linked Receptors
Antitarget
ALK3, ALK4, ALK5, ALK6, BMPR2, TGFBR2, AMPK, KDR/VEGFR2
Pathway
Angiogenesis
Stem Cells
Tyrosine Kinase/Adaptors
TGF-beta/Smad
Primary Target
BMP and Other Activin Receptors
MOA
Inhibitor
ALK tyrosine kinase receptor inhibitor
Source data
