General
Preferred name
FIMEPINOSTAT
Synonyms
CUDC 907 ()
CUDC-907 ()
PI3K/HDAC Inhibitor ()
Fimepinostat (CUDC-907) ()
CUDC907 ()
P&D ID
PD010586
CAS
1339928-25-4
Tags
available
drug candidate
Drug indication
Neuroblastoma
Acute myelogenous leukaemia
Solid tumour/cancer
Diffuse large B-cell lymphoma
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fimepinostat (CUDC-907) is an investigational dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol 3-kinase (PI3K) activity . The compound is orally available. (GtoPdb)
DESCRIPTION CUDC-907 is an investigational dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol 3-kinase (PI3K) activity . The compound is orally available.
DESCRIPTION CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. (BOC Sciences Bioactive Compounds)
Cell lines
16
Organisms
1
Compound Sets
14
AdooQ Bioactive Compound Library
A11153
BOC Sciences Bioactive Compounds
cudc-907-cas-1339928-25-4-item-84-462493
Cayman Chemical Bioactives
25651
ChEMBL Drugs
CHEMBL3622533
Drug Repurposing Hub
DrugBank
DB11891
DrugMAP
DMHIQDC
EU-OPENSCREEN Bioactive Compound Library
EOS100759
Guide to Pharmacology
8952
LINCS compound set
10371-101
MedChem Express Bioactive Compound Library
HY-13522
ReFrame library
Selleckchem Bioactive Compound Library
pi3k-hdac-inhibitor-i
TargetMol Bioactive Compound Library
T2078
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
508.16
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
2.14
TPSA
138.72
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
NF-??b
Apoptosis
Cell Cycle/DNA Damage
Epigenetics
PI3K/Akt/mTOR
Target
HDAC1
HDAC10
HDAC11
HDAC2
HDAC3
HDAC2, PIK3R1
HDAC
PI3K
Apoptosis related,HDAC,PI3K
MOA
PI3K inhibitor
Source data