General
Preferred name
Sapanisertib
Synonyms
MLN0128 ()
TAK-228 ()
INK-128 ()
INK 128 ()
INK128 ()
CB-228 ()
MLN-0128 ()
Sapanisertib (MLN0128) ()
INK 128,TAK-228 ()
Ink-128 ()
P&D ID
PD010560
CAS
1224844-38-5
Tags
available
drug candidate
probe
Drug indication
Multiple myeloma
Coronavirus Disease 2019 (COVID-19)
Breast cancer
Drug Status
investigational
Max Phase
Phase 2
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
225
No orthogonal probes found
Similar probes
2
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sapanisertib (INK128) is an ATP-competitive inhibitor of mTOR in mTORC1 and mTORC2 complexes, that exhibits potent anti-tumour activity .
The compound also has antimalarial activity. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The compound also has antimalarial activity. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
INK128 is an ATP-competitive inhibitor of mTOR in mTORC1 and mTORC2 complexes, exhibiting potent anti-tumour activity .
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
13
Organisms
0
Compound Sets
21
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LINCS compound set
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
PKIDB
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
309.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
4
cLogP
2.38
TPSA
121.67
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
PI3K/Akt/mTOR signaling
Autophagy
PI3K/Akt/mTOR
Target
MTOR
PI3K??
MTOR, PIK3CA, PIK3CD, PIK3CG
Member status
member
MOA
Mammalian Target of Rapamycin (mTOR
FRAP1) Inhibitors
Phosphatidylinositol 3-Kinase delta (PI3Kdelta) Inhibitors
Phosphatidylinositol 3-Kinase alpha (PI3Kalpha) Inhibitors
Phosphatidylinositol 3-Kinase gamma (PI3Kgamma) Inhibitors
mTOR inhibitor
Therapeutic Class
Antiviral Agents
Source data
