General
Preferred name
SB-271046
Synonyms
SB 271046 hydrochloride ()
SB-271046A ()
SB 271046 (Hydrochloride) ()
SB 271046A ()
SB271046 ()
SB 271046 ()
SB-271046 (hydrochloride) ()
P&D ID
PD010546
CAS
209481-24-3
209481-20-9
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective PAR2 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective, orally active 5-HT6 antagonist
(Tocriscreen Plus)
DESCRIPTION
SB-271046 is found to be a competitive antagonist with a pA2 of 8.7 in the functional adenylyl cyclase assay which is in good agreement with its binding affinity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
451.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
4.08
TPSA
70.67
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT6 Receptors
MOA
Antagonist
serotonin receptor antagonist
Target
HTR6
5-HT6 antagonist
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Solubility
Soluble in DMSO (100 mM), and ethanol (50 mM)
Source data
