General
Preferred name
IMD-0354
Synonyms
IMD 0354 ()
IKK2 Inhibitor V ()
TCMDC-125465 ()
P&D ID
PD010541
CAS
978-62-1
634914-41-3
Tags
available
drug candidate
Drug indication
Acne vulgaris
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION IMD-0354 (IKK2 Inhibitor V) is a selective IKK¦Â inhibitor which inhibits NF-¦ÊB activity[1]. IMD0354 inhibits TNF-¦Á induced NF-¦ÊB transcription activity with an IC50 of 1.2 uM[2].
PRICE 73
DESCRIPTION IMD-0354 (IKK2 Inhibitor V) is an IKK?? inhibitor that blocks I??B?? phosphorylation in the NF-??B pathway.
DESCRIPTION Potent inhibitor of shp2 and shp1 PTP (Tocris Bioactive Compound Library)
DESCRIPTION inhibitor of IKK-2 (Tocriscreen Total)
DESCRIPTION IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor that blocks IκBα phosphorylation in the NF-κB pathway. (TargetMol Bioactive Compound Library)
Cell lines
7
Organisms
3
Compound Sets
15
AdooQ Bioactive Compound Library
A12837
Axon Medchem Screening Library
2725
Cayman Chemical Bioactives
17290
ChEMBL Drugs
CHEMBL536151
Clinical kinase drugs
Drug Repurposing Hub
DrugMAP
DMOFSLE
EUbOPEN Chemogenomics Library
EUB0001989
MedChem Express Bioactive Compound Library
HY-10172
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
imd-0354
TargetMol Bioactive Compound Library
T6141
Tocris Bioactive Compound Library
2611
Tocriscreen Total
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
383.01
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
5.34
TPSA
49.33
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
NF-??
NF-κB
Targets
IKBKB
Target
IKK
IKKβ
IKK-2 inhibitor
I¦ÊB/IKK
Primary Target
I?B Kinase
MOA
Inhibitor
IKK-2 (IKK-beta) Inhibitors
NF-kappaB (NFKB) Activation Inhibitors
IKK inhibitor, NFkB pathway inhibitor
Member status
member
Recommended Cell Concentration
None
Source data