General
Preferred name
SLC-0111
Synonyms
U 104 ()
NSC-213841 ()
MST-104 ()
NSC 213841 ()
U-104 ()
U-104 (NSC-213841 ()
MST-104) ()
MST-104, NSC 213841, SLC-0111, WBI-5111 ()
4-{[(4'-Fluorophenyl)Carbamoyl]Amino}Benzenesulfonamide ()
SLC0111 ()
U104 ()
P&D ID
PD010539
CAS
178606-66-1
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Neoplasm
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SLC-0111 is a carbonic anhydrase (CA) IX/XII inhibitor that is being investigated for anti-neoplastic potential . SLC-0111 is selective for the transmembrane CA isoforms IX and XII, compared to the cytosolic CA I and II isoforms. CA IX and XII are expressed predominantly in the hypoxic tumour microenvironment. Their inhibition promotes a significant antitumour/antimetastatic effect and reduces cancer stem cell numbers. The crystal structure of SLC-0111 bound to CA II has been resolved (see PDB ID 3N4B) . (GtoPdb)
DESCRIPTION U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1][2].
PRICE 34
DESCRIPTION Highly potent and selective DOT1L inhibitor; cell permeable (Tocris Bioactive Compound Library)
DESCRIPTION Potent carbonic anhydrase (CA) IX and XII inhibitor (Tocriscreen Plus)
DESCRIPTION SLC-0111 is a potent carbonic anhydrase inhibitor. (Enamine Bioactive Compounds)
DESCRIPTION U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM). (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A14959
Cayman Chemical Bioactives
16717
ChEMBL Drugs
CHEMBL1615281
Concise Guide to Pharmacology 2019/20
10149
Concise Guide to Pharmacology 2021/22
10149
Drug Repurposing Hub
DrugBank
DB18815
Enamine Bioactive Compounds
EBC-06760
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100470
Guide to Pharmacology
10149
MedChem Express Bioactive Compound Library
HY-13513
ReFrame library
Selleckchem Bioactive Compound Library
u-104
TargetMol Bioactive Compound Library
T2017
Tocris Bioactive Compound Library
4540
Tocriscreen Plus
4540
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
309.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.12
TPSA
101.29
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Carbonic Anhydrase
Carbonic anhydrase I
Carbonic anhydrase II
Carbonic anhydrase IX
CAXII
CA1, CA12, CA2, CA9
Primary Target
Carbonic Anhydrases
MOA
Inhibitor
Carbonic anhydrase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data