General
Preferred name
T0070907
Synonyms
T 0070907 ()
N-(4-Pyridyl)-(2-chloro-5-nitrophenyl)carboxamide ()
TO070907 ()
P&D ID
PD010536
CAS
313516-66-4
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
T0070907 is a potent PPAR¦Ã antagonist with a Ki of 1 nM.
PRICE
45
DESCRIPTION
T0070907(IC50=1 nM) , an effective and specific PPAR?? inhibitor, with the >800-fold selectivity over PPAR?? and PPAR??.
DESCRIPTION
Potent liver X receptor (LXR) agonist; also CAR inverse agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly potent and selective PPARgamma antagonist
(Tocriscreen Plus)
DESCRIPTION
Highly potent and selective PPARγ antagonist
(Tocriscreen Total)
DESCRIPTION
T0070907 was identified as a potent and selective PPARgamma antagonist. T0070907 blocked PPARgamma function in both cell-based reporter gene and adipocyte differentiation assays. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
T0070907 is a potent and selective PPARgamma inhibitor.
(Enamine Bioactive Compounds)
DESCRIPTION
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
23
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CovalentInDB
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
277.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.9
TPSA
85.13
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Target
PPAR
PPARα
PPARγ
PPARδ
PPARG
DNA-PK,PPAR,RAD51
Primary Target
PPAR?
MOA
Antagonist
PPARgamma antagonist
PPAR receptor antagonist
Member status
member
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
