General
Preferred name
IKK16
Synonyms
IKK 16 ()
IKK Inhibitor VII ()
IKK-16 ()
IKK 16 (hydrochloride) ()
IKK-16 (IKK Inhibitor VII) ()
IKK-16 (hydrochloride) ()
P&D ID
PD010532
CAS
1186195-62-9
873225-46-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION IKK 16 is a selective I¦ÊB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM.
PRICE 137
DESCRIPTION IKK 16 (IKK Inhibitor VII) is a selective I??B kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
DESCRIPTION IKK 16 hydrochloride is a selective I¦ÊB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively[1]. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM[2].
DESCRIPTION IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective inhibitor of IKK (Tocriscreen Plus)
DESCRIPTION Selective inhibitor of IKK (Tocriscreen Total)
DESCRIPTION Potent, selective VEGFR-2 inhibitor (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
14
AdooQ Bioactive Compound Library
A12836
Cayman Chemical Bioactives
13313
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100669
EUbOPEN Chemogenomics Library
EUB0000647
LINCS compound set
10228-102
MedChem Express Bioactive Compound Library
HY-13687
HY-13687A
Selleckchem Bioactive Compound Library
ikk-16
TargetMol Bioactive Compound Library
T6176
Tocris Bioactive Compound Library
2539
Tocriscreen Plus
2539
Tocriscreen Total
ZINC Tool Compounds
ZINC000013831229
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
483.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
6
Aromatic Ring Count
4
cLogP
5.8
TPSA
61.36
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
NF-¦ÊB
NF-??
Autophagy
Apoptosis
Immunology/Inflammation
Membrane Transporter/Ion Channel
Target
IKK
IKK1
IKK2
LRRK2
IKBKB
Interleukin Related
NF-κB
P-glycoprotein
PKD
TNF Receptor
I¦ÊB/IKK,LRRK2
Primary Target
I?B Kinase
MOA
Inhibitor
IKK inhibitor
Recommended Cell Concentration
None
Source data