General
Preferred name
ZM 306416
Synonyms
ZM 306416 hydrochloride ()
CB 676475 ()
CB-676475 ()
ZM306416 ()
ZM-306416 ()
P&D ID
PD010526
CAS
690206-97-4
196603-47-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ZM-306416 is reported as an inhibitor of VEGFR and EGFR . Hennequin et al (1999) report selectivity for VEGFR2 (KDR) over VEGFR1 (Flt-1) (ZM-306416 is compound 4 in ). (GtoPdb)
DESCRIPTION ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 ¦ÌM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.
PRICE 48
DESCRIPTION ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 ??M), can also inhibit EGFR (IC50<10 nM).
DESCRIPTION ZM306416 is a vascular endothelial growth factor receptor (VEGFR) antagonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION Inhibitor of VEGF receptor tyrosine kinase (Tocriscreen Total)
DESCRIPTION ZM 306416 hydrochloride is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase with > 3-fold selectivity over FGFR-1. ZM 306416 hydrochloride inhibits activity of KDR and FLT VEGF receptors (IC50 = 100 nM and 2 μM, respectively). (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
zm306416-cas-690206-97-4-item-418967
zm-306416-hydrochloride-cas-196603-47-1-item-170446
Cayman Chemical Bioactives
16968
Drug Repurposing Hub
DrugMAP
DMXON4L
Guide to Pharmacology
8245
MedChem Express Bioactive Compound Library
HY-13785
Selleckchem Bioactive Compound Library
zm-306416
TargetMol Bioactive Compound Library
T1754
Tocriscreen Total
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
333.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.18
TPSA
56.27
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ABL
SRC
VEGFR
VEGFR1
EGFR, FLT1, FLT4, KDR
MOA
Abl kinase inhibitor, SRC inhibitor, VEGFR inhibitor
Pathway
Angiogenesis
Cytoskeletal Signaling
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Source data