General
Preferred name
Go 6983
Synonyms
Goe 6983 ()
G? 6983 ()
Go-6983 ()
GO6983 ()
Gö 6983 ()
GOE 6983, G? 6983 ()
Gö 6983 ()
P&D ID
PD010518
CAS
133053-19-7
1340-95-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Gö6983 is a pan-PKC inhibitor . (GtoPdb)
DESCRIPTION DNA methyltransferase and cytidine deaminase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. (BOC Sciences Bioactive Compounds)
Compound Sets
17
AdooQ Bioactive Compound Library
A13790
Axon Medchem Screening Library
2466
BOC Sciences Bioactive Compounds
go6983-cas-133053-19-7-item-84-256612
Cayman Chemical Bioactives
13311
Concise Guide to Pharmacology 2017/18
5192
Concise Guide to Pharmacology 2019/20
5192
Concise Guide to Pharmacology 2021/22
5192
Concise Guide to Pharmacology 2023/24
5192
Drug Repurposing Hub
DrugMAP
DMKVTZN
EU-OPENSCREEN Bioactive Compound Library
EOS100634
Guide to Pharmacology
5192
LINCS compound set
10211-101
MedChem Express Bioactive Compound Library
HY-13689
Selleckchem Bioactive Compound Library
go-6983
TargetMol Bioactive Compound Library
T6313
Tocris Bioactive Compound Library
2285
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
442.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
3.65
TPSA
79.36
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Cytoskeletal Signaling
Epigenetics
TGF-beta/Smad
Target
PKC??
PRKCA, PRKCB, PRKCD, PRKCG, PRKCZ
PKC inhibitor
PKC
Primary Target
Protein Kinase C
MOA
Inhibitor
protein kinase inhibitor
Source data