General
Preferred name
WZ811
Synonyms
WZ 811 ()
P&D ID
PD010517
CAS
55778-02-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM)[1].
PRICE 30
DESCRIPTION Ghrelin receptor (GHS-R1a) antagonist (Tocris Bioactive Compound Library)
DESCRIPTION WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM). (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
9
Axon Medchem Screening Library
1620
Cayman Chemical Bioactives
13639
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EUbOPEN Chemogenomics Library
EUB0000824
MedChem Express Bioactive Compound Library
HY-15478
Selleckchem Bioactive Compound Library
wz-811
TargetMol Bioactive Compound Library
T1739
Tocris Bioactive Compound Library
3951
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
290.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.7
TPSA
49.84
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CXCR
CXCR4
CXCR4 antagonist
Primary Target
Chemokine CXC Receptors
MOA
Antagonist
CC chemokine receptor antagonist
Pathway
Autophagy
GPCR/G protein
Immunology/Inflammation
Recommended Cell Concentration
100 nM
Source data