General
Preferred name
HOMATROPINE METHYLBROMIDE
Synonyms
Homatropine (methylbromide) ()
Homatropine methobromide ()
Methylhomatropine (bromide) ()
NSC-757048 ()
Methylbromure d'homatropine ()
Homapin-10 ()
Homatropini methylbromidum ()
Homatropine methylbromide component of hycodan ()
Equipin ()
NSC-34399 ()
Homapin ()
Homapin-5 ()
Metilbromuro de homatropina ()
Homatropine methylbromide component of hydropane ()
Homatropine methylbromide component of tussigon ()
P&D ID
PD010484
CAS
80-49-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Gastrointestinal disease
First approval
1943
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
369.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
-0.96
TPSA
46.53
Fraction CSP3
0.59
Chiral centers
4.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
AChR antagonist
Target
mAChR
AChR
Pathway
GPCR/G protein
Neuronal Signaling
Source data
