General
Preferred name
BUTEIN
Synonyms
2¡¯,3,4,4¡¯-tetrahydroxy Chalcone ()
2',3,4,4'-tetrahydroxy Chalcone ()
2’,3,4,4’-tetrahydroxy Chalcone ()
P&D ID
PD010472
CAS
487-52-5
21849-70-7
Tags
available
drug candidate
nuisance
obsolete probe
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 ¦ÌM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 ¦ÌM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC).
PRICE
82
DESCRIPTION
Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. The use of these compounds in the treatment of breast cancer on the estrogen ground has been taken into account.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Butein is a Arachidonate 5-lipoxygenase inhibitor with IC50 = 4.6 nM
(Enamine Bioactive Compounds)
DESCRIPTION
Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator. It sensitizes HeLa cells to Cisplatin by targeting FoxO3a via the AKT and ERK/p38 MAPK pathways.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
272.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.41
TPSA
97.99
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Chalcone
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Apoptosis
Autophagy
JAK/STAT Signaling
Metabolism
Tyrosine Kinase/Adaptors
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
MOA
EGFR inhibitor, SRC inhibitor
Target
ACE
EGFR
Phosphodiesterase (PDE)
p60c-src
phosphodiesterase
Solubility
DMSO: >50 mg/mL
Source data
