General
Preferred name
FLORFENICOL
Synonyms
Thiamphenicol, 3-fluoro ()
Nuflor ()
Aquafen ()
(-)-Florfenicol ()
SCH-25298 ()
SCH-25298,(-)-Florfenicol ()
NSC-759287 ()
Florfenicol component of zeleris ()
SCH 25298 ()
Florfenicol component of osurnia ()
Florfenicol-d3 ()
P&D ID
PD010412
CAS
73231-34-2
76639-94-6
2213400-85-0
Tags
available
drug
Approved by
FDA
Drug Status
approved
vet_approved
investigational
experimental
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Florfenicol is a fluorinated synthetic analogue of and classed as an amphenicol antibacterial compound. It is mainly used in veterinary medicine. (GtoPdb)
PRICE 29
DESCRIPTION Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions[6][7].
DESCRIPTION Florfenicol (SCH-25298), a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Haemophilus somnus, and Pasteurella multocida, for therapy of bovine interdigital phlegmon (foot rot, infectious pododermatitis, acute interdigital necrobacillosis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. This compound is also used in aquaculture and is approved for use in the United States for the therapy of enteric septicemia in catfish.
DESCRIPTION Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis, it is used as an antibacterial. (Enamine Bioactive Compounds)
DESCRIPTION Florfenicol (Aquafen) is a fluorinated synthetic analog of thiamphenicol. In the United States, florfenicol is currently used to treat bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, to treat bovine interdigital phlegmon associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
14
Cayman Chemical Bioactives
19458
28538
ChEMBL Drugs
CHEMBL1241590
Drug Repurposing Hub
DrugBank
DB11413
DrugBank Approved Drugs
DB11413
DrugCentral
5543
Enamine Bioactive Compounds
EBC-47475
Guide to Pharmacology
12923
MedChem Express Bioactive Compound Library
HY-B1374
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
florfenicol
TargetMol Bioactive Compound Library
T0454
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
357.0
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
1.38
TPSA
83.47
Fraction CSP3
0.42
Chiral centers
2.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Antibiotic
protein synthesis inhibitor
Pathway
Microbiology&virology
Anti-infection
Indication
bovine respiratory disease (BRD)
Target
antibiotic
Bacterial
Source data