General
Preferred name
FLUOROMETHOLONE ACETATE
Synonyms
NSC 47438 ()
Flarex ()
Eflone ()
Oxylone acetate ()
NSC 47438,Oxylone acetate ()
U-17,323 ()
Fluorometholone acetate component of tobrasone ()
U-17323 ()
Fluorometholone 17-acetate ()
NSC-47438 ()
P&D ID
PD010403
CAS
3801-06-7
Tags
available
drug
Approved by
FDA
First approval
1986
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 ¦ÌM and 17.5 ¦ÌM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3].
DESCRIPTION Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye. (TargetMol Bioactive Compound Library)
Compound Sets
10
ChEMBL Approved Drugs
CHEMBL1201064
ChEMBL Drugs
CHEMBL1201064
Drug Repurposing Hub
DrugCentral
4647
DrugCentral Approved Drugs
4647
MedChem Express Bioactive Compound Library
HY-B1471
NIH Mechanistic Set
ReFrame library
Selleckchem Bioactive Compound Library
fluorometholone-acetate
TargetMol Bioactive Compound Library
T6503
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
418.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
3.49
TPSA
80.67
Fraction CSP3
0.71
Chiral centers
8.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Carbonic Anhydrase
Glucocorticoid Receptor
NR3C1
Indication
eye inflammation
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Source data