General
Preferred name
Thiamet G
Synonyms
thiamet-g ()
P&D ID
PD010392
CAS
1009816-48-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiamet-G is a O-GlcNAcase inhibitor and is widely used as a pharmacological tool to investigate the role of O-GlcNAcase (and its potential for modulation) in tau-related dementias . It has been used as a lead scaffold for the development of O-GlcNAcase inhibitors that are optimised for clinical utility, such as . (GtoPdb)
DESCRIPTION Potent O-GlcNAcase inhibitor (Tocriscreen Plus)
DESCRIPTION Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
13
Cayman Chemical Bioactives
13237
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100533
EUbOPEN Chemogenomics Library
EUB0001088
Guide to Pharmacology
10509
MedChem Express Bioactive Compound Library
HY-12588
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
thiamet-g
TargetMol Bioactive Compound Library
T6056
Tocris Bioactive Compound Library
4390
Tocriscreen Plus
4390
VGSC-DB
NA0526
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
248.08
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
-1.49
TPSA
94.31
Fraction CSP3
0.89
Chiral centers
5.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Autophagy
Neuronal Signaling
Target
O-GlcNAcase
MGEA5
OGA
Primary Target
Other Hydrolases
MOA
Inhibitor
N-Acetyl-beta-D-Glucosaminidase (O-GlcNAcase, OGA) Inhibitors
OGLcNACase inhibitor
GLCNAC phosphotransferase inhibitor
Member status
member
VGSC Target
Nav1.5
Recommended Cell Concentration
None
Source data