General
Preferred name
LOSMAPIMOD
Synonyms
GSKAHAB, GW856553, GW856553X ()
GSK-AHAB ()
SB856553 ()
GW856553X ()
GW856553 ()
GW856553, GSK-AHAB ()
Losmapimod (GW856553X) ()
FTX-1821 ()
FTX1821 ()
GSKAHAB ()
GW-856553 ()
GW-856553X ()
GW 856553X ()
P&D ID
PD010391
CAS
585543-15-3
Tags
available
drug candidate
Drug indication
Acute coronary syndrome
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Losmapimod is a p38 mitogen-activated kinase α/β inhibitor. It was originally developed by GlaxoSmithKline for cardiovascular disease, but this failed to show efficacy. Fulcrum acquired the drug and are repurposing it for the treatment of the progressive muscle wasting disorder facioscapulohumeral muscular dystrophy (FSHD) based on evidence that p38α regulates expression of the FSHD-related gene DUX4 . (GtoPdb)
DESCRIPTION Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pKis of 8.1 and 7.6 for p38¦Á and p38¦Â, respectively[1].
PRICE 60
DESCRIPTION Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38??/??).
DESCRIPTION Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β). (TargetMol Bioactive Compound Library)
Compound Sets
18
AdooQ Bioactive Compound Library
A12526
Cayman Chemical Bioactives
13614
ChEMBL Drugs
CHEMBL1088752
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12270
DrugMAP
DMIL37Z
EU-OPENSCREEN Bioactive Compound Library
EOS101776
Guide to Pharmacology
7835
LINCS compound set
10402-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1088752
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL1088752
MedChem Express Bioactive Compound Library
HY-10402
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
losmapimod-gw856553x
TargetMol Bioactive Compound Library
T2277
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
383.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.86
TPSA
71.09
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
MAPK14,MAPK11
Target
MAPK14
Apoptosis related,Autophagy,p38 MAPK
MAPK11
MAPK13
MAPK12
p38 MAPK
p38α
p38β
MOA
p38 MAPK inhibitor
Pathway
Autophagy
MAPK
MAPK/ERK Pathway
Source data