General
Preferred name
LOSMAPIMOD
Synonyms
GSKAHAB, GW856553, GW856553X ()
GW856553X ()
SB856553 ()
GSK-AHAB ()
GW856553 ()
FTX-1821 ()
FTX1821 ()
GSKAHAB ()
GW-856553 ()
GW-856553X ()
Losmapimod (GW856553X) ()
GW856553, GSK-AHAB ()
GW 856553X ()
P&D ID
PD010391
CAS
585543-15-3
Tags
available
drug candidate
Drug indication
Acute coronary syndrome
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Losmapimod is a p38 mitogen-activated kinase α/β inhibitor. It was originally developed by GlaxoSmithKline for cardiovascular disease, but this failed to show efficacy. Fulcrum acquired the drug and are repurposing it for the treatment of the progressive muscle wasting disorder facioscapulohumeral muscular dystrophy (FSHD) based on evidence that p38α regulates expression of the FSHD-related gene DUX4 . (GtoPdb)
Compound Sets
17
AdooQ Bioactive Compound Library
A12526
Cayman Chemical Bioactives
13614
ChEMBL Drugs
CHEMBL1088752
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DB12270
DrugMAP
DMIL37Z
EU-OPENSCREEN Bioactive Compound Library
EOS101776
Guide to Pharmacology
7835
LINCS compound set
10402-101
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1088752
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL1088752
MedChem Express Bioactive Compound Library
HY-10402
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
losmapimod-gw856553x
TargetMol Bioactive Compound Library
T2277
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
383.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.86
TPSA
71.09
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
MAPK14,MAPK11
Pathway
MAPK
Autophagy
MAPK/ERK Pathway
Target
p38??
MAPK14
MAPK11
MAPK13
MAPK12
p38 MAPK
Apoptosis related,Autophagy,p38 MAPK
MOA
p38 MAPK inhibitor
Source data