General
Preferred name
AZ2858
Synonyms
AZD2858 ()
AZD 2858 hydrochloride ()
AZD 2858 ()
P&D ID
PD010380
CAS
486424-20-8
Tags
available
probe
Probe info
Probe type
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
18
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AZD2858 is an orally active inhibitor of glycogen synthase kinase 3 beta (GSK-3β) .
(GtoPdb)
DESCRIPTION
AZD2858 is a potent, orally active GSK-3 inhibitor, with IC50s of 0.9 and 5 nM for GSK-3¦Á and GSK-3¦Â, respectively, used in the research of fracture healing.
PRICE
101
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
AZD2858 is a potent and selective GSK3β inhibitor with Ki value of 4.9 nM. It was shown to promote osteoblast differentiation in human adipose-derived stem cells (hADSC) in vitro.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
453.16
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
1.31
TPSA
134.41
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GSK-3
GSK3B
GSK-3ß inhibitor
MOA
glycogen synthase kinase inhibitor
Pathway
PI3K/Akt/mTOR
Stem Cell/Wnt
PI3K/Akt/mTOR signaling
Stem Cells
Target class
Kinase
Target subclass
CMGC
Source data
