General
Preferred name
AZD-1981
Synonyms
AZD1981 ()
AZD 1981 ()
Azd 1981 ()
P&D ID
PD010376
CAS
802904-66-1
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD1981 was an investigational compound being assessed as a potential treatment for asthma. Mechanistically it is a potent, orally active, selective and reversible antagonist of the DP2 receptor (CRTH2).
This compound is now included for repurposing in the AstaZeneca's Open Innovation Pharmacology Toolbox. It was also Case Study (2) in the AZ 2014 review paper . (GtoPdb)
DESCRIPTION AZD1981 is the antagonist for GPR44 (also known also PTGDR2, DP2 or CRTh). AZD1981 blocks the binding of PGD2 to CRTH2. AZD1981 exhibits immunomodulatory effects and can be used in research of chronic spontaneous urticaria[1][2].
PRICE 39
DESCRIPTION AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying the treatment and basic science of Asthma, Postmenopausal, Pharmakokinetic, Asthma Patients, and Drug Interaction, among others. (TargetMol Bioactive Compound Library)
Compound Sets
17
AdooQ Bioactive Compound Library
A13186
Axon Medchem Screening Library
2145
Cayman Chemical Bioactives
20763
ChEMBL Drugs
CHEMBL1914489
Concise Guide to Pharmacology 2021/22
7680
Concise Guide to Pharmacology 2023/24
7680
Concise Guide to Pharmacology 2025/26
7680
Drug Repurposing Hub
DrugBank
DB11946
DrugMAP
DMMCL9F
EUbOPEN Chemogenomics Library
EUB0000772
Guide to Pharmacology
7680
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1914489
MedChem Express Bioactive Compound Library
HY-15950
ReFrame library
Selleckchem Bioactive Compound Library
azd1981
TargetMol Bioactive Compound Library
T6399
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
388.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.8
TPSA
71.33
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CRTh2 (DP2) receptor
Prostaglandin Receptor
PTGDR2
CRTH2 antagonist
GPR
MOA
CRTH receptor antagonist
Pathway
Endocrinology/Hormones
GPCR/G protein
Immunology/Inflammation
Recommended Cell Concentration
1 uM
Source data