General
Preferred name
TAK-632
Synonyms
P&D ID
PD010363
CAS
1228591-30-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively.
PRICE 47
DESCRIPTION TAK-632, a potent pan-Raf inhibitor (GenScript, 2020), is characterized by its molecular weight [M] for [C 22 H 19 FN 2 O 2] of 362.4 by LC-MS, with a purity of 99% (HPLC). The compound exhibits white to off-white solid form and has a melting point [M] ranging from 178??C to 182??C (GenScript, 2020). Its solubility profile includes DMSO, in which it is soluble to 100mM (GenScript, 2020).
DESCRIPTION TAK-632 is a pan-RAF kinase inhibitor . It binds human BRAF in the DFG-out conformation. TAK-632 inhibits RIPK1/3-induced necrosome formation and necroptosis, and this action was shown to be mediated by direct ligand interaction with RIPK1 and RIPK3 (and inhibition of their kinase activities) . (GtoPdb)
DESCRIPTION TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50 value of 2.4 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION TAK-632, a potent pan-Raf inhibitor (GenScript, 2020), is characterized by its molecular weight [M] for [C 22 H 19 FN 2 O 2] of 362.4 by LC-MS, with a purity of 99% (HPLC). The compound exhibits white to off-white solid form and has a melting point [M] ranging from 178°C to 182°C (GenScript, 2020). Its solubility profile includes DMSO, in which it is soluble to 100mM (GenScript, 2020). (TargetMol Bioactive Compound Library)
Cell lines
9
Organisms
0
Compound Sets
12
AdooQ Bioactive Compound Library
A13323
BOC Sciences Bioactive Compounds
tak-632-cas-1228591-30-7-item-84-462598
Cayman Chemical Bioactives
16285
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100854
Guide to Pharmacology
10387
LINCS compound set
10409-101
MedChem Express Bioactive Compound Library
HY-15767
Selleckchem Bioactive Compound Library
tak-632
TargetMol Bioactive Compound Library
T1886
ZINC Tool Compounds
ZINC000068208189
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
554.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
6.65
TPSA
104.11
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Aurora B
Aurora Kinase
b-RAF
c-Raf
FGFR3
PDGFRβ
Raf
BRAF
MOA
Raf inhibitor
Pathway
Angiogenesis
Cell Cycle/Checkpoint
Chromatin/Epigenetic
MAPK
Tyrosine Kinase/Adaptors
Cell Cycle/DNA Damage
Epigenetics
MAPK/ERK Pathway
Source data