General
Preferred name
TMP269
Synonyms
TMP 269 ()
P&D ID
PD010352
CAS
1314890-29-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TMP269 is a histone deacetylase (HDAC) inhibitor with specificity for class IIa HDACs (HDACs 4, 5, 7 and 9) . (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
A14128
Cayman Chemical Bioactives
17738
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMSMQE7
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100940
Guide to Pharmacology
7491
Mcule NIBR MoA Box Subset
MCULE-1221301034
MedChem Express Bioactive Compound Library
HY-18360
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
tmp269
TargetMol Bioactive Compound Library
T1857
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
514.13
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
4
cLogP
5.36
TPSA
90.14
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
NF-??b
NF-¦ªb
Cell Cycle/DNA Damage
Epigenetics
Target
HDAC4
HDAC5
HDAC7
HDAC9
HDAC
Member status
member
Source data