General
Preferred name
SH-4-54
Synonyms
SH4-54 ()
Salicylic acid derivative 5 ()
SH-​4-​54 ()
P&D ID
PD010344
CAS
1456632-40-8
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively.
PRICE 187
DESCRIPTION SH-4-54 is an inhibitor of signal transducer and activator of transcription 3 (STAT3), IC50 = 4.4 μM. It also inhibits histone deacetylase, IC50 = 2.6μM. (Enamine Bioactive Compounds)
DESCRIPTION SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
11
AdooQ Bioactive Compound Library
A14249
Cayman Chemical Bioactives
25982
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM3OZ0F
Enamine Bioactive Compounds
EBC-13762
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100411
MedChem Express Bioactive Compound Library
HY-16975
ReFrame library
Selleckchem Bioactive Compound Library
sh-4-54
TargetMol Bioactive Compound Library
T6669
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
610.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
5.98
TPSA
94.99
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.18
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
STAT
STAT3
STAT5
Pathway
JAK/STAT Signaling
Stem Cells
Stem Cell/Wnt
Source data