General
Preferred name
GNE-0877
Synonyms
GNE 0877 ()
GNE0877 ()
DNL201 ()
DNL-201 ()
P&D ID
PD010334
CAS
1374828-69-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Parkinson disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC50 of 3 nM and a Ki of 0.7 nM. GNE0877 can be used for the research of neuroscience[1].
PRICE 148
DESCRIPTION GNE-0877 (renamed DNL201; Denali Therapeutics) is a potent and selective, brain penetrant small molecule inhibitor of LRRK2 (leucine-rich repeat kinase 2) , a kinase whose aberrant activation is identified in a subset of patients with Parkinson's disease. LRRK2 ihnibitors are being developed as potential disease-modifying agents as therapeutics for Parkinson's disease. This mechanism is predicted to correct lysosomal dysfunction and neurodegenerative sequelae. (GtoPdb)
DESCRIPTION GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
11
AdooQ Bioactive Compound Library
A13969
BOC Sciences Bioactive Compounds
gne-0877-cas-1374828-69-9-item-84-462277
Cayman Chemical Bioactives
16251
ChEMBL Drugs
CHEMBL3122113
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EOS100973
Guide to Pharmacology
9393
MedChem Express Bioactive Compound Library
HY-15796
ReFrame library
Selleckchem Bioactive Compound Library
gne-0877
TargetMol Bioactive Compound Library
T6031
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
339.14
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.04
TPSA
91.45
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
LRRK2
Pathway
Autophagy
Source data