General
Preferred name
KN-62
Synonyms
KN62 ()
KN 62 ()
P&D ID
PD010322
CAS
127191-97-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII) and also acts as a non-competitive antagonist of the purinergic receptor P2RX7 . For details of a non-isomeric form of this compound used in kinase screens please see our ligand entry .
(GtoPdb)
DESCRIPTION
KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
16
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LINCS compound set
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
721.2
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
7
Aromatic Ring Count
6
cLogP
5.13
TPSA
130.08
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.18
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
CaMK??
CaMKII
AKT1, CAMK2A, CHEK1, LCK, MAPK1, MAPK11, MAPK12, MAPK14, MAPK8, P2RX7, PRKCA, ROCK1, RPS6KB1, SGK1
CaMK
P2X Receptor
Member status
member
MOA
P2X7 Receptor Antagonists
Calmodulin-Dependent Protein Kinase II (CaMK-II) Inhibitors
Calmodulin Antagonists
"P2X7 Receptor Antagonists
Calmodulin Antagonists"
calcium/calmodulin dependent protein kinase inhibitor, purinergic receptor antagonist
Source data
