General
Preferred name
GW0742
Synonyms
GW 0742 ()
CHEMBL38508 ()
GW610742 ()
GW0742X ()
P&D ID
PD010263
CAS
317318-84-6
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
4
No orthogonal probes found
Similar probes
1
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GW0742 is a potent PPAR¦Â and PPAR¦Ä agonist, with an IC50 of 1 nM for human PPAR¦Ä in binding assay, and EC50s of 1 nM, 1.1 ¦ÌM and 2 ¦ÌM for human PPAR¦Ä, PPAR¦Á, and PPAR¦Ã, respectively.
PRICE
65
DESCRIPTION
GW0742 (GW610742) is an effective and specific PPAR?? agonist (EC50: 1 nM/1.1 ??M/2 ??M, for human PPAR??/??/??).
MOA
Agonist
(Chemical Probes.org)
DESCRIPTION
Agonist selective for estrogen-related receptors ERRbeta and ERRgamma
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly selective, potent PPARdelta agonist
(Tocriscreen Plus)
DESCRIPTION
Highly selective, potent PPARδ agonist
(Tocriscreen Total)
DESCRIPTION
GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
NURSA ligand set
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
471.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
6.34
TPSA
59.42
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Target
Peroxisome proliferator-activated receptor delta
PPAR
PPARα
PPARγ
PPARδ
PPARD
Primary Target
PPAR?
MOA
Agonist
PPAR receptor agonist
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target class
Nuclear Hormone Receptor
Target subclass
Nuclear Receptor 1C2
Recommended Cell Concentration
1 uM
Source data
