General
Preferred name
TCS 359
Synonyms
FLT3 Inhibitor ()
TCS-359 ()
Flt-3 inhibitor ()
P&D ID
PD010262
CAS
301305-73-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This is compound 25 in .
(GtoPdb)
DESCRIPTION
TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM[1].
PRICE
38
DESCRIPTION
Potent FLT3 inhibitor
(Tocriscreen Plus)
DESCRIPTION
Potent FLT3 inhibitor
(Tocriscreen Total)
DESCRIPTION
Deoxycytidine kinase (dCK) substrate
(Tocris Bioactive Compound Library)
DESCRIPTION
TCS-359 is a potent inhibitor of FLT3 with IC50 of 42 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
TCS 359 is an inhibitor of receptor-type tyrosine-protein kinase FLT3.
(Enamine Bioactive Compounds)
DESCRIPTION
TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
360.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.0
TPSA
90.65
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Target
FLT3
MOA
Inhibitor
FLT inhibitor
FLT3 inhibitor
Pathway
Protein Tyrosine Kinase/RTK
Angiogenesis
Tyrosine Kinase/Adaptors
Source data
