General
Preferred name
VU 0364770
Synonyms
ML128 Analog ()
ML182 Analog ()
ML292 ()
VU0364770 ()
VU0364770 (hydrochloride) ()
P&D ID
PD010257
CAS
61350-00-3
1414842-70-8
Tags
available
drug candidate
probe
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
Probe sources
MLP Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective 5-HT2A antagonist (Tocris Bioactive Compound Library)
DESCRIPTION VU 0364770 is systemically active positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 4 (mGluR4) (EC50: 290 nM). It showed efficacy alone or when administered in combination with L-DOPA or an adenosine 2A (A2A) receptor antagonist, in several rodent PD models. (BOC Sciences Bioactive Compounds)
Compound Sets
13
AdooQ Bioactive Compound Library
A12139
Axon Medchem Screening Library
1845
BOC Sciences Bioactive Compounds
vu-0364770-cas-61350-00-3-item-84-463468
Cayman Chemical Bioactives
22927
Drug Repurposing Hub
DrugMAP
DMXY980
Guide to Pharmacology
6234
MedChem Express Bioactive Compound Library
HY-100588A
HY-100588
MLP Probes
NBK133426
MLSMR Probes +
Selleckchem Bioactive Compound Library
vu-0364770
TargetMol Bioactive Compound Library
T6727
Tocris Bioactive Compound Library
4469
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
232.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.99
TPSA
41.99
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
probe analog
Probe
Antitarget
mGlu1,mGlu2, mGlu3, mGlu5, mGlu6, mGlu7, mGlu8, PanLabs (Ricerca), Millipore
Target
rmGlu4, hmGlu4
mGluR4
GRM4
mGLuR4 PAM
mGluR
GluR
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Primary Target
Glutamate (Metabotropic) Group III Receptors
MOA
Modulator
glutamate receptor positive allosteric modulator
Solubility
Soluble in DMSO
Source data