General
Preferred name
ML204
Synonyms
ML204 HCl ()
ML 204 ()
ML204 (hydrochloride) ()
ML204 hydrochloride ()
ML-204 ()
P&D ID
PD010253
CAS
5465-86-1
2070015-10-8
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ML204 is a dual inhibitor of TRPC4 and TRPC5 channels . Although it is sometimes referred to as being selective for TRPC4, it exhibits only 9-fold preference for TRPC4 compared to TRPC5.
(GtoPdb)
DESCRIPTION
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].
PRICE
40
PRICE
180
DESCRIPTION
ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4?? currents activated by intracellular dialysis via ??-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).
DESCRIPTION
Find general TRPC agonist and specific TRPC4 agonist
(MLP Probes)
DESCRIPTION
Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
ML-204 selectively blocks transient receptor potential canonical 4 channels.
(Enamine Bioactive Compounds)
DESCRIPTION
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
(TargetMol Bioactive Compound Library)
DESCRIPTION
ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MLP Probes
MLSMR Probes +
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
226.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.53
TPSA
16.13
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
Probe
Antitarget
TRPC6 inhibitor_Ach activation
Target
TRPC4 inhibitor _┬╡OR activation
TRPC4
TRPC5
TRP Channel
TRPC4, TRPC5
Primary Target
TRPC
MOA
Blocker
transient receptor potential channel antagonist
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
