General
Preferred name
ML167
Synonyms
NCGC00188654 ()
CID44968231 ()
CID 44968231 ()
ML-167 ()
(5-(4-(((5-Methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol ()
P&D ID
PD010251
CAS
1285702-20-6
Tags
available
probe
Probe info
Probe type
experimental probe
Probe selectivity
protein-selective
Probe sources
MLP Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1].
PRICE 50
DESCRIPTION The Cdc2-like kinases (ClkΓÇÔs) and the dual-specificity tyrosine phosphorylation-regulated kinases (DyrkΓÇÔs) are two classes of enzymes that have been shown to phosphorylate specific proteins within the spliceosome@ therefore, they are considered important targets for the modulation of gene splicing events. In addition to the agents reported in these reports, there is only one other reported Clk4 inhibitor, which was found to be somewhat promiscuous versus a kinase panel. Small molecule inhibitors of all 4 isoforms of the Clk family and both the Dyrk1A and Dyrk1B family, with varying selectivity profiles, will be of great utility to the study of these kinases as modulators of gene splicing, as well as other cellular events. The probe described here represents the first fully selective inhibitor of Cdc2-like kinase 4 (Clk4). This probe compound will be useful for the scientific community in unraveling the phenotype associated solely with Clk4 down-regulation without complication arising from the inhibition of related kinases. Particularly, given the reported role of the Clk family as a specific modulator of SR proteins, this probe will be useful in exploring the specific functions of Clk4 in terms of gene splicing. (MLP Probes)
DESCRIPTION shows inhibitory activity against dual specificity protein kinase CLK4, CLK2. (Enamine Bioactive Compounds)
DESCRIPTION ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. (BOC Sciences Bioactive Compounds)
DESCRIPTION ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
12
BOC Sciences Bioactive Compounds
ml167-cas-1285702-20-6-item-84-463389
Cayman Chemical Bioactives
18098
Drug Repurposing Hub
Enamine Bioactive Compounds
EBC-07914
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0001026
Mcule NIBR MoA Box Subset
MCULE-1499460430
MedChem Express Bioactive Compound Library
HY-15951
MLP Probes
NBK56236
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
ml167
TargetMol Bioactive Compound Library
T2670
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
335.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
3.9
TPSA
84.32
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Antitarget
Clk1, Clk2, Clk3, Dyrk1A/1 B
Target
Cdc2- like kinase 4 (Clk4)
CDK
CLK1
CLK2
CLK4
DYRK1B
CLK4, DYRK1B
DYRK
Member status
virtual
MOA
CLK and Dryk1A inhibitor
CLK inhibitor, DYRK inhibitor
Pathway
Cell Cycle/Checkpoint
Tyrosine Kinase/Adaptors
Cell Cycle/DNA Damage
Protein Tyrosine Kinase/RTK
Solubility
Soluble in DMF, DMSO, Ethanol
Recommended Cell Concentration
None
Source data