General
Preferred name
GOSERELIN
Synonyms
ICI 118630 ()
ICI-118630 acetate ()
Fertilan ()
Zoladex ()
GOSERELIN ACETATE ()
Goserelin (acetate) ()
ICI-118630 (acetate) ()
Goserelin Acetate ()
ICI 118,630 ()
ICI-118630 ()
Novgos ()
Zoladex LA ()
P&D ID
PD010242
CAS
145781-92-6
65807-02-5
1233494-97-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1989
Drug Status
approved
Drug indication
LHRH Agonist
Breast cancer
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Goserelin is indicated for:; ; - Use in combination with flutamide for the management of locally confined carcinoma of the prostate; - Palliative treatment of advanced carcinoma of the prostate; - The management of endometriosis; - Use as an endometrial-thinning agent prior to endometrial ablation for dysfunctional uterine bleeding; - Use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women
DESCRIPTION
Goserelin is a synthetic analogue of the decapeptide, gonadotropin releasing hormone (GnRH). It is known as a 'superagonist'.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
1268.64
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
18
Rotatable Bonds
31
Ring Count
6
Aromatic Ring Count
4
cLogP
-2.9
TPSA
493.39
Fraction CSP3
0.51
Chiral centers
9.0
Largest ring
6.0
QED
0.01
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GNRH Receptor
GNRHR
GNRHR, LHCGR
Pathway
GPCR/G protein
Apoptosis
Member status
member
MOA
gonadotropin releasing hormone agonist
gonadotropin releasing factor hormone receptor agonist
Indication
prostate cancer, breast cancer, endometriosis
Disease Area
oncology, obstetrics/gynecology
Therapeutic Class
Anticancer Agents
Source data
