General
Preferred name
tetrahydrofolic acid
Synonyms
THFA ()
Tetrahydropteroylglutamic acid ()
L-5,6,7,8-Tetrahydrofolic acid ()
L-Tetrahydrofolic acid ()
?(6R,S)-5,6,7,8-Tetrahydrofolic acid (hydrochloride) ()
P&D ID
PD010236
CAS
135-16-0
150731-85-4
Tags
natural product
drug
available
Drug indication
Malnutrition
Drug Status
nutraceutical
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tetrahydrofolic acid is a folic acid derivative. It is a cofactor in many bio-reactions, especially in the metabolism of amino acids and nucleic acids.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
445.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
8
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.28
TPSA
211.56
Fraction CSP3
0.32
Chiral centers
2.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Dietary supplement
Pathway
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
Solubility
DMSO (Slightly), Methanol (Slightly)
Source data
