General
Preferred name
HISTIDINE
Synonyms
L-Histidine hydrochloride ()
Glyoxaline-5-alanine ()
L-(-)-Histidine ()
[14C]histidine ()
[3H]histidine ()
L-histidine ()
L-Hisidine (monohydrocholoride) ()
L-Histidine (hydrochloride hydrate) ()
H-His-OH.HCl.H2O ()
L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O ()
L-?Histidine ()
L-Histidine monohydrochloride monohydrate ()
HISTIDINE MONOHYDROCHLORIDE ()
[3H]histidine ()
Histidina ()
NSC-137773 ()
FEMA NO. 3694 ()
Sunactyl ls 9610 ()
Photonyl ()
Osmhydran ls 8453 ()
P.p.a.a. ()
NSC-257867 ()
Histidine hydrochloride ()
[14C]histidine ()
P&D ID
PD010235
CAS
5934-29-2
150-35-6
7006-35-1
26062-48-6
71-00-1
645-35-2
Tags
available
drug candidate
drug
Approved by
FDA
Drug indication
Discovery agent
congenital heart disease
Drug Status
approved
investigational
nutraceutical
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport.
DESCRIPTION L-Histidine is an amino acid commonly found as a component of total parenteral nutrition. It is an essential amino acid that is required for the production of histamine. L-Histidine inhibits ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Ki=1 nM), it also activates human recombinantcarbonic anhydrase I, Ka= 0.03 µM. (Enamine Bioactive Compounds)
DESCRIPTION L-Histidine (L-(-)-Histidine) is a semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, L-Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. L-Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals. (TargetMol Bioactive Compound Library)
DESCRIPTION Histamine precursor (LOPAC library)
Compound Sets
17
Cayman Chemical Bioactives
33904
ChEMBL Drugs
CHEMBL17962
CHEMBL1256578
Concise Guide to Pharmacology 2017/18
3310
4670
4623
Concise Guide to Pharmacology 2019/20
3310
4670
4623
Concise Guide to Pharmacology 2021/22
3310
4670
4623
Concise Guide to Pharmacology 2023/24
3310
4670
4623
DrugBank
DB00117
DrugCentral
1377
DrugCentral Approved Drugs
1377
DrugMAP
DMJ5BDQ
DMVUF71
Enamine Bioactive Compounds
EBC-44106
Guide to Pharmacology
3310
4670
4623
LOPAC library
MedChem Express Bioactive Compound Library
HY-N0832
HY-N0833
HY-W014423
ReFrame library
Selleckchem Bioactive Compound Library
l-histidine
l-histidine-monohydrochloride-monohydrate
TargetMol Bioactive Compound Library
T2A2532
External IDs
108
Properties
(calculated by RDKit )
Molecular Weight
155.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.64
TPSA
92.0
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
5.0
QED
0.54
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Mitochondrial Metabolism
Apoptosis
Reactive Oxygen Species (ROS)
Pathway
Metabolism
Metabolic Enzyme/Protease
Immunology/Inflammation
NF-κB
Source data