General
Preferred name
S-adenosyl methionine
Synonyms
Ademetionine disulfate tosylate ()
SAMe ()
S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt ()
S-Adenosyl-L-methionine (tosylate) ()
S-Adenosyl-L-methionine (disulfate tosylate) ()
S-Adenosyl methionine (tosylate) ()
Ademetionine (tosylate) ()
AdoMet (tosylate) ()
Ademetionine (disulfate tosylate) ()
S-Adenosyl methionine (disulfate tosylate) ()
AdoMet (disulfate tosylate) ()
AdoMet ()
S-Adenosyl-L-methionine disulfate tosylate ()
S-(5'-Adenosyl)-L-methionine tosylate ()
S-(5'-Adenosyl)-L-methionine (tosylate) ()
S-(5’-Adenosyl)-L-methionine (sulfate tosylate) ()
P&D ID
PD010234
CAS
97540-22-2
52248-03-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION S-Adenosyl-L-methionine (Ademetionine) disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine disulfate tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine disulfate tosylate also has anti?proliferative, pro?apoptotic and anti?metastatic roles in cancers. S-Adenosyl-L-methionine disulfate tosylate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].
DESCRIPTION This compound is sold as a nutritional supplement in the US and Canada and is approved as a prescription drug in some EU countries (approval date not available), where it is used to treat depression, liver disorders, fibromyalia and osteoarthritis. (GtoPdb)
PRICE 31
DESCRIPTION S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the disulfate-tosylate mixed salt comprising diastereoisomers of ademetionine ions. Ademetionine exhibits anti-inflammatory properties and has been utilized in the treatment of chronic liver disease. (TargetMol Bioactive Compound Library)
DESCRIPTION S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3]. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A16149
Cayman Chemical Bioactives
17595
16376
Concise Guide to Pharmacology 2017/18
4786
Concise Guide to Pharmacology 2019/20
4786
Concise Guide to Pharmacology 2021/22
4786
Concise Guide to Pharmacology 2023/24
4786
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100773
Guide to Pharmacology
4786
MedChem Express Bioactive Compound Library
HY-W017770
HY-B0617A
Selleckchem Bioactive Compound Library
ademetionine-disulfate-tosylate
s-(5-adenosyl)-l-methionine-p-toluenesulfonate-salt
TargetMol Bioactive Compound Library
T6752
T4447
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
399.14
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
5
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
-1.92
TPSA
182.63
Fraction CSP3
0.6
Chiral centers
6.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
APE1(Ref-1)
Apoptosis
Endogenous Metabolite
Anti-infection
Indication
depression, attention-deficit/hyperactivity disorder (ADHD)
MOA
methyltransferase stimulant, phosphodiesterase inhibitor
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolic Enzyme/Protease
Source data