General
Preferred name
phenylalanine
Synonyms
(S)-2-Amino-3-phenylpropionic acid ()
3-Phenyl-L-alanine ()
(S)-2-Amino-3-phenylpropionic acid-15N ()
L-Phenylalanine-15N ()
L-phenylalanine ()
FEMA NO. 3585 ()
Fenilalanina ()
NSC-79477 ()
L-Phenylalanine ()
Laevo-phenyl alanine ()
Phenylalanine ()
L-Phenylalanine-13C6 ()
P&D ID
PD010232
CAS
17585-69-2
10549-09-4
63-91-2
29700-34-3
180268-82-0
Tags
available
drug
Approved by
FDA
Drug indication
Central Nervous System Neoplasm
Malnutrition
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
The supposed antidepressant effects of L-phenylalanine may be due to its role as a precursor in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
The mechanism of L-phenylalanine's possible antivitiligo activity is not well understood. It is thought that L-phenylalanine may stimulate the production of melanin in the affected skin
The mechanism of L-phenylalanine's possible antivitiligo activity is not well understood. It is thought that L-phenylalanine may stimulate the production of melanin in the affected skin
PRICE
29
DESCRIPTION
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at ??2?? calcium channels.
DESCRIPTION
Phenylalanine is an amino acid commonly found as a component of total parenteral nutrition. Phenylalanine is a precursor of melanin, dopamine, noradrenalin, and thyroxine.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.
(TargetMol Bioactive Compound Library)
DESCRIPTION
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a K i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) ( K B of 573 μM ) and non-NMDARs , respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
84
Molecular Weight
165.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.64
TPSA
63.32
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Endogenous Metabolite
iGluR
α2δ calcium channels
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Therapeutic Class
Dietary supplement
Source data
