General
Preferred name
DOXYLAMINE
Synonyms
DOXYLAMINE SUCCINATE ()
Doxylamine chlorotheophyllinate ()
Doxylamine (D5 succinate) ()
Decapryn ()
Doxylamine (succinate) ()
Meraprina ()
Unisom ()
NSC-74772 ()
Hoggar n ()
Doxylamine succinate component of bonjesta ()
Donormyl ()
Alsodorm ()
Donormil ()
Dormidina ()
Doxylamine succinate component of bendectin ()
Doxylamine hydrogen succinate ()
Doxylamine succinate component of diclectin ()
Doxy-Sleep-Aid ()
Gittalun ()
Doxylamine succinate component of diclegis ()
Doxilamina ()
Doxylamine-d5 (succinate) ()
P&D ID
PD010224
CAS
562-10-7
469-21-6
1216840-94-6
Tags
available
drug
Approved by
FDA
First approval
1948
Drug indication
infection
Morning sickness
allergic disease
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Doxylamine is an antihistamine.
(GtoPdb)
DESCRIPTION
H1 Histamine receptor antagonist
(LOPAC library)
DESCRIPTION
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
22
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
270.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.92
TPSA
25.36
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Target
Histamine Receptor
HRH1
H1 receptor
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
Indication
sedative
MOA
Histamine Receptor antagonist
ATC
R06AA59
R06AA09
Toxicity type
reproductive
Therapeutic Class
Hypnotics and Sedatives
Source data
