General
Preferred name
NOREPINEPHRINE
Synonyms
NOREPINEPHRINE TARTRATE ()
Norepinephrine Bitartrate ()
L(-)-Norepinephrine bitartrate ()
noradrenaline ()
L-Noradrenaline ()
Levophed ()
Levonoradrenaline ()
Aktamin ()
Nor-Epirenan ()
Levonor ()
Arterenol ()
Noradrenaline bitartrate ()
noradrenaline hydrochloride ()
Adrenor ()
(-)-Norepinephrine ()
Norepinephrine (hydrochloride) ()
Norepinephrine (bitartrate monohydrate) ()
Norepinephrine (tartrate) ()
Levarterenol (hydrochloride) ()
L-Noradrenaline (hydrochloride) ()
Levarterenol ()
Levarterenol (bitartrate monohydrate) ()
L-Noradrenaline (bitartrate monohydrate) ()
Levarterenol (tartrate) ()
L-Noradrenaline (tartrate) ()
Arterenol, Levarterenol, L-Noradrenaline ()
Noradrenaline bitartrate monohydrate ()
Norepinephrine hydrochloride ()
(?)-Norepinephrine ()
NOREPINEPHRINE BITARTRATE ()
(-)-Norepinephrine (bitartrate hydrate) ()
(-)-noradrenaline ()
R-norepinephrine ()
Noradrenaline ()
Nor adrenalin ()
Norepinefrina ()
NSC-757246 ()
Arterenol, tartrate, monohydrate ()
Norepinephrine d-bitartrate ()
Norepinephrine bitartrate monohydrate ()
Levarterenol Bitartrate ()
Norepinephrine bitartrate in 5% dextrose ()
Binodrenal ()
NSC-169106 ()
Noradrenaline tartrate ()
Noradrenaline (as tartrate) ()
L-(-)-Norepinephrine ()
P&D ID
PD010223
CAS
69815-49-2
51-40-1
108341-18-0
138-65-8
4899-05-2
51-41-2
55-27-6
329-56-6
Tags
available
drug
Approved by
FDA
First approval
1950
Drug indication
Cardiovascular disease
Sepsis
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates ¦Á1, ¦Á2, ¦Â1 receptors[1][2][3][4].
DESCRIPTION Marketed formulations may contain noradrenaline tartrate (PubChem CID 25127519). (GtoPdb)
PRICE 29
DESCRIPTION Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the ??-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells.
DESCRIPTION Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates ¦Á1, ¦Á2, ¦Â1 receptors[1][2][3][4].
PRICE 29
DESCRIPTION Norepinephrine bitartrate acts directly on the ??- and ??-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.
DESCRIPTION Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active (Tocris Bioactive Compound Library)
DESCRIPTION Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator. Noradrenaline modulates the gain of evoked activity, especially in sensory areas. (BOC Sciences Bioactive Compounds)
DESCRIPTION Norepinephrine is the US name for noradrenaline, a catecholamine with multiple roles including as a hormone and a neurotransmitter. It performs its action by being released into the synaptic cleft, where it acts on adrenergic receptors, followed by the signal termination, either by degradation of norepinephrine, or by uptake by surrounding cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells. (TargetMol Bioactive Compound Library)
DESCRIPTION Adrenergic neurotransmitter; vasoconstrictor (LOPAC library)
DESCRIPTION Adrenal medullary stress hormone, mediator of the fight-or-flight response; and the primary neurotransmitter in the post-ganglionic sympathetic (adrenergic) nervous system. (BOC Sciences Bioactive Compounds)
DESCRIPTION Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
32
AdooQ Bioactive Compound Library
A11306
BOC Sciences Bioactive Compounds
noradrenaline-bitartrate-monohydrate-cas-108341-18-0-81501
l-noradrenaline-cas-51-41-2-373891
norepinephrine-hydrochloride-cas-329-56-6-item-84-108668
Cayman Chemical Bioactives
16673
ChEMBL Approved Drugs
CHEMBL1437
CHEMBL1434513
ChEMBL Drugs
CHEMBL1437
CHEMBL1434513
Concise Guide to Pharmacology 2017/18
505
Concise Guide to Pharmacology 2019/20
505
Concise Guide to Pharmacology 2021/22
505
Concise Guide to Pharmacology 2023/24
505
Drug Repurposing Hub
DrugBank
DB00368
DrugBank Approved Drugs
DB00368
DrugCentral
1960
DrugCentral Approved Drugs
1960
DrugMAP
DMOUC09
DrugMAP Approved Drugs
DMOUC09
EU-OPENSCREEN Bioactive Compound Library
EOS101643
EUbOPEN Chemogenomics Library
EUB0000903
Guide to Pharmacology
505
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1437
CHEMBL1356607
MedChem Express Bioactive Compound Library
HY-13715C
HY-13715B
HY-13715
HY-13715A
NCATS Inxight Approved Drugs
X4W3ENH1CV
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
noradrenaline-bitartrate-monohydrate-levophed
norepinephrine
norepinephrine-hydrochloride
TargetMol Bioactive Compound Library
T7044
T0871
The Spectrum Collection
Tocris Bioactive Compound Library
5169
ZINC Tool Compounds
ZINC000000057624
External IDs
106
Properties
(calculated by RDKit )
Molecular Weight
169.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.09
TPSA
86.71
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha, beta1
Target
Adrenergic Receptor
¦Â1-adrenergic receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, PAH, SLC18A1, SLC18A2
Endogenous Metabolite
MMP-2
MMP-9
α1-adrenoceptor
α2A-adrenoceptor
β1-adrenoceptor
Pathway
Autophagy
GPCR/G protein
Metabolism
Neuroscience
Proteases/Proteasome
Metabolic Enzyme/Protease
Neuronal Signaling
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Adrenergic Receptor agonist
Agonist
MMP activator
alpha-Adrenoceptor Agonists
beta-Adrenoceptor Agonists
"alpha-Adrenoceptor Agonists
beta-Adrenoceptor Agonists"
Member status
member
Indication
hypertension, urticaria, headache, seasonal affective disorder
Disease Area
cardiology, allergy, neurology/psychiatry
Therapeutic Class
Vasoconstrictor Agents
Solubility
Soluble in Methanol (Slightly), Water (Sparingly)
Soluble in Aqueous Acid (Slightly), DMSO (Slightly)
Recommended Cell Concentration
100 nM
Source data