General
Preferred name
CIDOFOVIR
Synonyms
Cidofovir (dihydrate) ()
(S)-HPMPC dihydrate ()
HPMPC ()
GS 0504 ()
(S)-HPMPC ()
Cidofovir (Vistide) ()
CIDOFOVIR ANHYDROUS ()
Cidofovir hydrate ()
HPMPC,Vistide,GS 0504 ()
Cidofovir dihydrate ()
Anhydrous cidofovir ()
Bmy-28167 ()
Bbs-1067 ()
GS-0504 ()
NSC-742135 ()
HPMPC dihydrate ()
Vistide ()
P&D ID
PD010222
CAS
113852-37-2
149394-66-1
Tags
available
prodrug
drug
Approved by
FDA
First approval
1996
Drug indication
viral disease
Cytomegalovirus infection
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
PRICE
56
DESCRIPTION
Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis- an infection of the retina of the eye in people with AIDS
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
19
Compound Sets
19
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
279.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.66
TPSA
147.9
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CMV
DNA/RNA Synthesis
Apoptosis
Endogenous Metabolite
Orthopoxvirus
CMV,DNA/RNA Synthesis
Pathway
Anti-infection
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
MOA
DNA/RNA Synthesis inhibitor
DNA polymerase inhibitor
Indication
acquired immunodeficiency syndrome (AIDS), cytomegalovirus retinitis
ATC
J05AB12
Therapeutic Class
Anti-HIV Agents
Source data
