General
Preferred name
TRIHEXYPHENIDYL
Synonyms
TRIHEXYPHENIDYL HYDROCHLORIDE ()
1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-, hydrochloride, mixt. with n-methyl-n-(2-phenylethyl)benzeneethanamine hydrochloride ()
Benzhexol ()
(S)-Trihexyphenidyl ()
(R)-Trihexyphenidyl ()
Tremin ()
Trihexyphenidyl HCl ()
Artane ()
Trihexyphenidyl-D,L Hydrochloride ()
Trihexyphenidyl hydrochloride ()
Benzhexol hydrochloride, Artane hydrochloride ()
Trihexylphenedyl ()
Parkan ()
DL-trihexyphenidyl hydrochloride ()
Aparkane ()
Trihexyphenidyli hydrochloridum ()
NSC-757357 ()
Broflex ()
Agitane ()
Bentex ()
Cyclodolum ()
Benzhexol hydrochloride ()
Parcopane ()
Triphedinon ()
Romparkin ()
Sedrina ()
Cyclodol ()
Apo-trihex ()
NSC-12268 ()
Trihexyphenidyle ()
Trihexifenidilo ()
Trihexyphenidyl (hydrochloride) ()
P&D ID
PD010217
CAS
52-49-3
144-11-6
58947-95-8
Tags
available
drug
Approved by
FDA
First approval
1949
Drug indication
Obesity
Dystonia
dystonic disorder
Parkinson disease
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.
TOXICITY Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Trihexyphenidyl causes agitation, confusion, and hallucinations due to its effects on the central nervous system. Untreated overdose may result in death, especially in children. Respiratory depression and cardiac arrest may be seen as premortal signs.
DESCRIPTION Trihexyphenidyl is an antispasmodic, antimuscarinic drug.
Marketed formulations may contain trihexyphenidyl hydrochloride (PubChem CID 66007). (GtoPdb)
DESCRIPTION Muscarinic acetylcholine receptor antagonist; centrally acting anticholinergic (LOPAC library)
DESCRIPTION Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson's disease. (Enamine Bioactive Compounds)
DESCRIPTION DL-trihexyphenidyl hydrochloride (Trihexyphenidyl HCl) is a muscarinic antagonist. (TargetMol Bioactive Compound Library)
DESCRIPTION Trihexyphenidyl is a Mucarinic Cholinergic receptor antagonist using for the treatment of Parkinson's disease. It also has a direct antispasmodic action on smooth muscle. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
28
BOC Sciences Bioactive Compounds
trihexylphenedyl-cas-144-11-6-item-84122
Cayman Chemical Bioactives
27643
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1092
CHEMBL1490
ChEMBL Drugs
CHEMBL1092
CHEMBL1490
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00376
DrugBank Approved Drugs
DB00376
DrugCentral
2745
DrugCentral Approved Drugs
2745
DrugMAP
DMB19L8
DrugMAP Approved Drugs
DMB19L8
DrugMatrix
Enamine Bioactive Compounds
EBC-07023
Enamine BioReference Compounds
Guide to Pharmacology
7315
JUMP-Target 1 Compound Set
5572
Ki Database
Benzhexol
(R)-Trihexyphenidyl
(S)-Trihexyphenidyl
Trihexyphenidyl
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1092
CHEMBL1490
NCATS Inxight Approved Drugs
6RC5V8B7PO
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
trihexyphenidyl-hydrochloride
TargetMol Bioactive Compound Library
T1328
The Spectrum Collection
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
301.24
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
4.33
TPSA
23.47
Fraction CSP3
0.7
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Muscarinic acetylcholine receptor M1
mAChR
CHRM3
AChR
Selectivity
Muscarinic
MOA
muscarinic acetylcholine receptor antagonist
Pathway
Neuroscience
Therapeutic Class
Antiparkinson Agents
Solubility
Soluble in DMSO
Source data