General
Preferred name
MEXILETINE
Synonyms
MEXILETINE HYDROCHLORIDE ()
Koe 117 ()
Mexiletene hydrochloride ()
KOE-1173 (hydrochloride) ()
Mexiletine HCl ()
KO1173 ()
KOE-1173 (hydrochloride)Mexiletine HCl ()
Mexiletine (hydrochloride) ()
KO1173,Mexitil ()
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride ()
KO-1173 ()
KO 1173 CL ()
Mexitil ()
Katen ()
KO-1173 CL ()
NSC-758639 ()
KO-1173-Cl ()
Mexitil P.L. ()
Dl-mexiletine ()
(rs)-mexiletine ()
mexiletine ()
P&D ID
PD010214
CAS
5370-01-4
31828-71-4
Tags
natural product
drug
available
Approved by
EMA
FDA
First approval
1985
Drug Status
investigational
approved
Drug indication
Cardiac Depressant (anti-arrhythmic)
Ventricular tachycardia
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Approved drug mexiletine is a racemic mixture of two enantiomers. The structure shown here does not specify stereochemistry and represents the mixture.
Marketed formulations may contain mexiletine hydrochloride (PubChem CID 21467). (GtoPdb)
DESCRIPTION Sodium channel blocker (LOPAC library)
DESCRIPTION Na+ channel blocker; antiarrhythmic agent (Tocriscreen Plus)
DESCRIPTION Blocks voltage-sensitive Na+ and Ca2+ channels (T-type) (Tocris Bioactive Compound Library)
DESCRIPTION Na+ channel blocker, antiarrhythmic agent (Tocriscreen Total)
DESCRIPTION Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
29
Axon Medchem Screening Library
3454
BOC Sciences Bioactive Compounds
1-2-6-dimethylphenoxy-2-propanamine-cas-5370-01-4-324984
Cayman Chemical Bioactives
23782
ChEMBL Approved Drugs
CHEMBL1200606
CHEMBL558
ChEMBL Drugs
CHEMBL1200606
CHEMBL558
DrugBank
DB00379
DrugBank Approved Drugs
DB00379
DrugCentral
1794
DrugCentral Approved Drugs
1794
DrugMAP
DMCTE9R
DrugMAP Approved Drugs
DMCTE9R
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2629
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200606
CHEMBL558
MedChem Express Bioactive Compound Library
HY-A0093
NCATS Inxight Approved Drugs
1U511HHV4Z
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
mexiletine-hcl
TargetMol Bioactive Compound Library
T1046
The Spectrum Collection
Tocris Bioactive Compound Library
2596
Tocriscreen Plus
2596
Tocriscreen Total
VGSC-DB
NA0039
NA0040
NA0041
NA0042
NA0043
NA0044
NA0045
NA0046
NA0047
NA0048
NA0049
NA0050
NA0051
NA0052
NA0053
NA5925
NA5926
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
179.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
2.03
TPSA
35.25
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Pathway
Membrane Transporter/Ion Channel
Metabolism
Target
AHR
Voltage-gated sodium channel
Na+ channel blocker
Sodium Channel
Primary Target
Voltage-gated Sodium (NaV) Channels
MOA
Blocker
Therapeutic Class
Antiarrhythmic Agents
VGSC Target
Nav1.1
Nav1.2
Nav1.5
Nav1.7
Nav1.8
Nav1.9
Source data