General
Preferred name
CREATINE
Synonyms
Methylguanidoacetic acid ()
Methylguanidoacetic acid monohydrate ()
Creatine ALS-08 ()
Creatine (monohydrate) ()
Creatine monohydrate ()
Cosmocair c 100 ()
Neotine ()
Kreatinum ()
NSC-8752 ()
Creatine (hydrate) ()
P&D ID
PD010201
CAS
6020-87-7
57-00-1
1093737-19-9
Tags
available
drug
Approved by
FDA
Drug indication
Motor neurone disease
Ulcerative colitis
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Creatine is a essential, non-proteinaceous amino acid found in all animals. It is synthesized in the kidney, liver, and pancreas from L-arginine, glycine and L-methionine. Following its biosynthesis, creatine is transported to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine (creatine phosphate). Phosphocreatine is a major energy storage form in the body. Supplemental creatine may have an energy-generating action during anaerobic exercise and may also have neuroprotective and cardioprotective actions.
PRICE
34
PRICE
29
DESCRIPTION
Creatine is a essential, non-proteinaceous amino acid derivative found in all animals. It is synthesized in the kidney, liver, and pancreas from L-arginine, glycine and L-methionine. In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate. The reaction is catalysed by creatine kinase, and the result is phosphocreatine. Phosphocreatine binds with adenosine diphosphate to convert it back to ATP. Creatine is used for nutritional supplementation, also for treating dietary shortage or imbalance.
(Enamine Bioactive Compounds)
DESCRIPTION
Creatine (Methylguanidoacetic acid) is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine functions as part of the cell's energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP <-> PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the human body, creatine is synthesized mainly in the liver by the use of parts from three different amino acids: arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles and the rest is stored in the brain, heart, and testes.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Creatine monohydrate (Methylguanidoacetic acid monohydrate) is a key player in the phosphagen energy system, especially in muscle and the brain. Creatine monohydrate is the primary source of ATP during high-intensity, short-term activities.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
56
Molecular Weight
131.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.1
TPSA
90.41
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Human Endogenous Metabolite
CKB, CKM, CKMT1A, CKMT2, GAMT, SLC6A8
Dopamine Receptor
Akt
PI3K
IFN,JAK
Member status
member
MOA
ADP to ATP Phosphate donor
Creatine Kinase substrate
Pathway
Metabolism
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
PI3K/Akt/mTOR
Source data
